8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Base Information

Chemical Name:8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride
CAS No.:1352087-55-8
Molecular Formula:C₁₈H₂₁N₃O₂*ClH
Molecular Weight:347.845
Hs Code.:

Synonyms:8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

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Chemical Property of 8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

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Technology Process of 8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

There total 6 articles about 8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352087-54-7
tert-butyl 8-carbamoyl-6-cyclopropyl-7-(4-methoxyphenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylate

: 1352087-55-8
8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Guidance literature:: With chloro-trimethyl-silane; In methanol; for 20h;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1352087-55-8
8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 20 h / 100 °C / Inert atmosphere

2: chloro-trimethyl-silane / methanol / 20 h

With chloro-trimethyl-silane; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; water; 1: Suzuki Coupling;

Reference yield:

: 1352087-49-0
1-tert-butyl 3-methyl 4-cyclopropanecarbonyl-piperazine-1,3-dicarboxylate

: 1352087-55-8
8-carbamoyl-6-cyclopropyl-7-(4-methoxy-phenyl)-1,2,3,4-dihydropyrrolo[1,2-a]pyrazine monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / methanol / 24 h

2.1: p-toluenesulfonyl chloride / Difluoromethane / 0.33 h

2.2: 0.33 h

3.1: N-Bromosuccinimide / dichloromethane / 1 h / -35 - -30 °C

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 20 h / 100 °C / Inert atmosphere

5.1: chloro-trimethyl-silane / methanol / 20 h

With N-Bromosuccinimide; chloro-trimethyl-silane; water; caesium carbonate; p-toluenesulfonyl chloride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; Difluoromethane; dichloromethane; water; 4.1: Suzuki Coupling;