1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

Base Information

Chemical Name:1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol
CAS No.:1280207-34-2
Molecular Formula:C₁₄H₁₂BrF₂NO₂
Molecular Weight:344.156
Hs Code.:

Synonyms:1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

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Chemical Property of 1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

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Technology Process of 1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

There total 4 articles about 1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 420-90-6
3-bromo-3,3-difluropropene

: 1267684-96-7
5-(4-bromophenyl)-3-methylisoxazole-4-carbaldehyde

: 1280207-34-2
1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

Guidance literature:: 3-bromo-3,3-difluropropene; 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde; With indium; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;

With water;

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280207-34-2
1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride / acetic acid / 1 h / 115 °C

2: lithium borohydride; ethanol / 60 °C

3: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

4: sodium iodide; indium / N,N-dimethyl-formamide / 20 °C

With indium; lithium borohydride; ethanol; hydroxylamine hydrochloride; 4-methylmorpholine N-oxide; sodium iodide; tetrapropylammonium perruthennate; In dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1280205-98-2
(5-(4-bromophenyl)-3-methylisoxazole-4-yl)methanol

: 1280207-34-2
1-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-2,2-difluoro-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

2: sodium iodide; indium / N,N-dimethyl-formamide / 20 °C

With indium; 4-methylmorpholine N-oxide; sodium iodide; tetrapropylammonium perruthennate; In dichloromethane; N,N-dimethyl-formamide;