Technology Process of (3S,4S)-N-Boc-3-(4-phenoxy-benzenesulfonamido)-4-(2-nitrobenzenedisulfido)pyrrolidine
There total 11 articles about (3S,4S)-N-Boc-3-(4-phenoxy-benzenesulfonamido)-4-(2-nitrobenzenedisulfido)pyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2.1: sodium azide; ammonium chloride / water; methanol / 65 °C
3.1: lipase Amano AK-20 / tert-butyl methyl ether / 72 h / 20 °C / Enzymatic reaction
4.1: triethylamine / dichloromethane / 0 - 20 °C
5.1: N,N-dimethyl-formamide / 6 h / 105 °C / Inert atmosphere
6.1: lithium hydroxide; methanol / tetrahydrofuran / 0 - 20 °C
7.1: triphenylphosphine; water / tetrahydrofuran / 20 - 65 °C
7.2: 0 - 20 °C
8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 6 h / 20 °C
9.1: water; methylamine / methanol / 0.17 h / Inert atmosphere
10.1: dichloromethane / 2 h / 20 °C
With
methanol; sodium azide; water; ammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; methylamine; lithium hydroxide; diethylazodicarboxylate;
lipase Amano AK-20;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium azide; ammonium chloride / water; methanol / 65 °C
2.1: lipase Amano AK-20 / tert-butyl methyl ether / 72 h / 20 °C / Enzymatic reaction
3.1: triethylamine / dichloromethane / 0 - 20 °C
4.1: N,N-dimethyl-formamide / 6 h / 105 °C / Inert atmosphere
5.1: lithium hydroxide; methanol / tetrahydrofuran / 0 - 20 °C
6.1: triphenylphosphine; water / tetrahydrofuran / 20 - 65 °C
6.2: 0 - 20 °C
7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 6 h / 20 °C
8.1: water; methylamine / methanol / 0.17 h / Inert atmosphere
9.1: dichloromethane / 2 h / 20 °C
With
methanol; sodium azide; water; ammonium chloride; triethylamine; triphenylphosphine; methylamine; lithium hydroxide; diethylazodicarboxylate;
lipase Amano AK-20;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;
