2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

Base Information

Chemical Name:2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide
CAS No.:329781-64-8
Molecular Formula:C₃₉H₃₆N₈O₇
Molecular Weight:728.764
Hs Code.:

2-azidomethyl-<i>N</i>-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1<i>H</i>-purin-2-yl)-benzamide

Synonyms:2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

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Chemical Property of 2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

There total 8 articles about 2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 329781-62-6
2-azidomethyl-N-[9-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-benzamide

: 329781-64-8
2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

Guidance literature:: With pyridine; at 20 ℃; for 2.5h;
DOI:10.1016/S0040-4039(00)02183-3

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 329781-64-8
2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetramethylguanidium azide / methanol; CCl₄ / 1.5 h / Heating

2: NaOH / methanol / 0.5 h / 20 °C

3: 100 percent / SOCl₂ / 1 h / Heating

4: pyridine / 3 h / 20 °C

5: 83 percent / pyridine / 2.5 h / 20 °C

With pyridine; sodium hydroxide; thionyl chloride; N,N,N′,N′-tetramethylguanidinium azide; In methanol; tetrachloromethane;
DOI:10.1016/S0040-4039(00)02183-3

Reference yield:

: 89-71-4
2-Methyl-benzoic acid methyl ester

: 329781-64-8
2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: NBS; (BzO)2 / CCl₄ / 1 h / Heating

2: tetramethylguanidium azide / methanol; CCl₄ / 1.5 h / Heating

3: NaOH / methanol / 0.5 h / 20 °C

4: 100 percent / SOCl₂ / 1 h / Heating

5: pyridine / 3 h / 20 °C

6: 83 percent / pyridine / 2.5 h / 20 °C

With pyridine; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; N,N,N′,N′-tetramethylguanidinium azide; dibenzoyl peroxide; In methanol; tetrachloromethane;
DOI:10.1016/S0040-4039(00)02183-3