(R)-2-N-acetamido-3-methoxypropionate benzyl ester

Base Information

• Chemical Name: (R)-2-N-acetamido-3-methoxypropionate benzyl ester
• CAS No.: 1620134-82-8
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282
• Mol file: 1620134-82-8.mol

Synonyms:(R)-2-N-acetamido-3-methoxypropionate benzyl ester

Chemical Property of (R)-2-N-acetamido-3-methoxypropionate benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-2-N-acetamido-3-methoxypropionate benzyl ester

There total 2 articles about (R)-2-N-acetamido-3-methoxypropionate benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-N-acetamido-3-hydroxypropionate benzyl ester (1620134-81-7) + methyl iodide (74-88-4) → (R)-2-N-acetamido-3-methoxypropionate benzyl ester (1620134-82-8)

Guidance literature:

With silver(l) oxide; In acetonitrile; at 20 ℃; for 36h; Inert atmosphere;

DOI:10.1021/jm500707r

Reference yield:

D-serine benzyl ester hydrochloride (60022-62-0,879278-55-4,151651-44-4) → (R)-2-N-acetamido-3-methoxypropionate benzyl ester (1620134-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / -20 °C / Inert atmosphere

1.2: 4 h / -20 °C / Inert atmosphere

2.1: silver(l) oxide / acetonitrile / 36 h / 20 °C / Inert atmosphere

With triethylamine; silver(l) oxide; In dichloromethane; acetonitrile;

DOI:10.1021/jm500707r

Reference yield:

(R)-2-N-acetamido-3-methoxypropionate benzyl ester (1620134-82-8) → (R)-2-N-acetamido-3-methoxypropionic acid (196601-67-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.5h;

DOI:10.1021/jm500707r

upstream raw materials:

(R)-2-N-acetamido-3-hydroxypropionate benzyl ester

methyl iodide

D-serine benzyl ester hydrochloride

Downstream raw materials:

(R)-2-N-acetamido-3-methoxypropionic acid