2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

Base Information

Chemical Name:2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide
CAS No.:1620658-24-3
Molecular Formula:C₂₁H₁₇F₆N₂O₂P
Molecular Weight:474.342
Hs Code.:

Synonyms:2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

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Chemical Property of 2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

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Technology Process of 2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

There total 6 articles about 2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1620658-22-1
2-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)-6-[(1,3-dioxoisoindolin-2-yl)methyl]pyridine 1-oxide

: 1620658-24-3
2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

Guidance literature:: With hydrazine hydrate; In methanol; at 90 ℃; for 18h; Inert atmosphere; Schlenk technique;
DOI:10.1002/ejoc.201400120

Reference yield:

: 628308-52-1
2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione

: 1620658-24-3
2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 12 h / 23 - 120 °C / Inert atmosphere; Schlenk technique

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 23 °C / Inert atmosphere; Schlenk technique

3: hydrazine hydrate / methanol / 18 h / 90 °C / Inert atmosphere; Schlenk technique

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.201400120

Reference yield:

: 1620658-20-9
2-{[6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridin-2-yl]methyl}isoindoline-1,3-dione

: 1620658-24-3
2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 23 °C / Inert atmosphere; Schlenk technique

2: hydrazine hydrate / methanol / 18 h / 90 °C / Inert atmosphere; Schlenk technique

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1002/ejoc.201400120