6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

Base Information

Chemical Name:6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline
CAS No.:638218-62-9
Molecular Formula:C₂₅H₃₀BNO₄S
Molecular Weight:451.394
Hs Code.:

Synonyms:6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

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Chemical Property of 6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

Chemical Property:

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Technology Process of 6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

There total 1 articles about 6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 638218-61-8
8-(3-bromo-phenyl)-6-(1-methanesulfonyl-1-methyl-ethyl)-quinoline

: 73183-34-3
bis(pinacol)diborane

: 638218-62-9
6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

Guidance literature:: With potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1016/j.bmcl.2008.01.004

Reference yield:

: 4858-85-9
2,3-dichloropyrazine

: 638218-62-9
6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

: 638220-27-6
8-[3-(3-chloro-pyrazin-2-yl)-phenyl]-6-(1-methanesulfonyl-1-methyl-ethyl)-quinoline

Guidance literature:: With sodium carbonate; Pd(IMes)2; In 1,4-dioxane; at 100 ℃; for 2h;

Reference yield:

: 638218-62-9
6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline

: 1019332-33-2
C₂₆H₂₃NO₄S

Guidance literature:: 6-(1-methanesulfonyl-1-methyl-ethyl)-8-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-quinoline; 4-bromobenzoic acid methyl, ethyl, or t-butyl ester; With sodium carbonate; triphenylphosphine; palladium diacetate; In propan-1-ol; at 80 ℃;

Further stages.; Saponification;
DOI:10.1016/j.bmcl.2008.01.004