2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan

Base Information

• Chemical Name: 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan
• CAS No.: 618913-78-3
• Molecular Formula: C₁₉H₉ClN₂O₂S
• Molecular Weight: 364.812
• Mol file: 618913-78-3.mol

Synonyms:2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan

Chemical Property of 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan

There total 4 articles about 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(4-carboxyphenyl)-5-(6-cyanobenzothiazol-2-yl)furan (618913-74-9) → 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan (618913-78-3)

Guidance literature:

With thionyl chloride; at 85 ℃; for 4h;

DOI:10.3390/80300342

Reference yield:

furfural (98-01-1) → 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan (618913-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaNO₂; hydrochloric acid / H₂O / 0.33 h / 5 °C

1.2: 60 percent / CuCl₂*2H₂O / acetone; H₂O / 48 h / 20 °C

2.1: 70 percent / pyridine / 4 h / Heating

3.1: 74 percent / thionyl chloride / 4 h / 85 °C

With pyridine; hydrogenchloride; thionyl chloride; sodium nitrite; In water;

DOI:10.3390/80300342

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 2-(4-chlorocarbonylphenyl)-5-(6-cyanobenzothiazol-2-yl)furan (618913-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaNO₂; hydrochloric acid / H₂O / 0.33 h / 5 °C

1.2: 60 percent / CuCl₂*2H₂O / acetone; H₂O / 48 h / 20 °C

2.1: 70 percent / pyridine / 4 h / Heating

3.1: 74 percent / thionyl chloride / 4 h / 85 °C

With pyridine; hydrogenchloride; thionyl chloride; sodium nitrite; In water;

DOI:10.3390/80300342

upstream raw materials:

2-(4-carboxyphenyl)-5-(6-cyanobenzothiazol-2-yl)furan

furfural

4-(5'-formylfuran-2'-yl)benzoic acid

4-amino-benzoic acid