1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one
CAS No.:145874-67-5
Molecular Formula:C₃₃H₂₅N₇O₇
Molecular Weight:631.604
Hs Code.:

Synonyms:1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

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Chemical Property of 1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

Chemical Property:

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Technology Process of 1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

There total 1 articles about 1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108895-98-3
benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

: 145874-66-4
1-(2,4-dinitrophenyl)-3-(chloromethyl)imidazole

: 145874-67-5
1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydride; Multistep reaction; 1.) DMF, 0 deg C, 1 h, 2.) DMF, 1 h;
DOI:10.1021/jm00078a018

Reference yield:

: 145874-67-5
1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

: 1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]methyl-3-amino-5-phenyl-2H-1,4-benzodiazepin-2-one hydrobromide

Guidance literature:: With hydrogen bromide; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jm00078a018

Reference yield:

: 145874-67-5
1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one

: (R,S)-N-(2,3-dihydro-1-(4-imidazolylmethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: HBr(g) / CH₂Cl₂ / 0.5 h / 0 °C

2: Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

3: thiophenol / dimethylformamide / 0.5 h / 23 °C

With hydrogen bromide; thiophenol; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00078a018