1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

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Chemical Name:1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol
CAS No.:1361220-57-6
Molecular Formula:C₂₃H₂₇F₆N₃O₄S₂
Molecular Weight:587.607
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

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Chemical Property of 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

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Technology Process of 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

There total 6 articles about 1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1361217-10-8
(3S)-3-methyl-4-(((2S)-4-(2-thiophenylsulfonyl)-2-piperazinyl)methyl)morpholine

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1361220-57-6
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; In toluene; at 100 ℃; for 15h; Inert atmosphere; Sealed tube; Heating;
DOI:10.1021/jm4016735

Reference yield:

: (3S)-3-methyl-4-((2R)-2-piperazinylmethyl)morpholine trihydrochloride

: 1361220-57-6
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 15 h / 100 °C / sealed vial; Inert atmosphere

With triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In dichloromethane; toluene;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1361220-57-6
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-(((3S)-3-methyl-4-morpholinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)-phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 16 h / 50 °C

2.2: 20 °C

3.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 6 h / 70 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 15 h / 100 °C / sealed vial; Inert atmosphere

With hydrogenchloride; borane-THF; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;