4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Base Information

Chemical Name:4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide
CAS No.:1313019-74-7
Molecular Formula:C₂₁H₁₅F₄N₃O₃
Molecular Weight:433.362
Hs Code.:

Synonyms:4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Suppliers and Price of 4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

There total 4 articles about 4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

: 115029-23-7
2-fluoro-5-(trifluoromethyl)benzoic acid

: 1313019-74-7
4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Guidance literature:: 2-fluoro-5-(trifluoromethyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.516667h;

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide; In N,N-dimethyl-formamide; for 12h;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1313019-74-7
4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 15.5 h / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere

3.2: 4 h / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.52 h

4.2: 12 h

With oxalyl dichloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 51727-15-2
4-chloro-2-pyridine carboxylic acid chloride hydrochloride

: 1313019-74-7
4-(4-(2-fluoro-5(trifluoromethyl)benzamido)phenoxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere

2.2: 4 h / 80 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.52 h

3.2: 12 h

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;