Z-LEU-TYR-NH2

Base Information

• Chemical Name: Z-LEU-TYR-NH2
• CAS No.: 17263-42-2
• Molecular Formula: C₂₃H₂₉N₃O₅
• Molecular Weight: 427.5
• Mol file: 17263-42-2.mol

Synonyms:Carbamicacid, [1-[(a-carbamoyl-p-hydroxyphenethyl)carbamoyl]-3-methylbutyl]-,benzyl ester, L- (8CI)

Chemical Property of Z-LEU-TYR-NH2

Chemical Property:

• PSA: 130.75000
• LogP: 3.72800
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Z-LEU-TYR-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-LEU-TYR-NH2

There total 4 articles about Z-LEU-TYR-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

Z-L-leucine hydroxysuccinimide ester (3397-35-1) + (S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride (53559-18-5,117888-79-6,117888-80-9,2442565-30-0) → benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate (17263-42-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.8b01466

Reference yield:

Boc-Tyr-OH (3978-80-1) → benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate (17263-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.83 h / 0 °C

1.2: 16.08 h / 0 - 25 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.8b01466

Reference yield:

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate (83351-75-1) → benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate (17263-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.8b01466

upstream raw materials:

Boc-Tyr-OH

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

Z-L-leucine hydroxysuccinimide ester

(S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride

Refernces