H-TYR-NH2 HCL

Base Information

• Chemical Name: H-TYR-NH2 HCL
• CAS No.: 53559-18-5
• Molecular Formula: C₉H₁₂N₂O₂*ClH
• Molecular Weight: 216.667
• Mol file: 53559-18-5.mol

Synonyms:Benzenepropanamide,a-amino-4-hydroxy-,monohydrochloride, (S)-; Benzenepropanamide, a-amino-4-hydroxy-, monohydrochloride, (aS)- (9CI); L-Tyrosinamidehydrochloride (6CI); L-Tyrosine amide hydrochloride; Tyrosine amidehydrochloride

Chemical Property of H-TYR-NH2 HCL

Chemical Property:

• PSA: 90.33000
• LogP: 2.39930
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

H-Tyr-NH2Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-TYR-NH2 HCL

There total 4 articles about H-TYR-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate (83351-75-1) → (S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride (53559-18-5,117888-79-6,117888-80-9,2442565-30-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.8b01466

Reference yield:

L-tyrosine hydrochloride (16870-43-2,282733-43-1) → (S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride (53559-18-5,117888-79-6,117888-80-9,2442565-30-0)

Guidance literature:

With hexamethylphosphorous triamide dichloride; ammonia; In dichloromethane; 1) 30 min, -20 deg C, 2) 4 h, r.t.;

Reference yield:

Boc-Tyr-OH (3978-80-1) → (S)-2-amino-3-(4-hydroxyphenyl)propanamide hydrochloride (53559-18-5,117888-79-6,117888-80-9,2442565-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.83 h / 0 °C

1.2: 16.08 h / 0 - 25 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.8b01466

upstream raw materials:

L-tyrosine hydrochloride

Boc-Tyr-OH

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

L-tyrosine

Downstream raw materials:

L-tyrosine

benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

C₂₇H₃₃N₄O₄⁽¹⁺⁾*I^(1-)

Refernces

• 1、 Appel, Rolf,Hiester, Ernst. "Dichlorotris(dimethylamino)phosphorane as a Dehydratisation Reagent for the Preparation of N-Protected Amino Acid Amides". . p. 2037 - 2040. Retrieved 2007/10/02.