1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

Base Information

Chemical Name:1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole
CAS No.:1287738-85-5
Molecular Formula:C₂₁H₁₄F₄N₂O
Molecular Weight:389.325
Hs Code.:

Synonyms:1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

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Technology Process of 1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

There total 6 articles about 1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 153934-67-9
C₁₄H₈BrF₃N₂

: 1287739-63-2
5-fluoro-2-methoxy-d3-phenylboronic acid

: 1287738-85-5
1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

Guidance literature:: With potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; water; at 60 - 70 ℃; Inert atmosphere;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1287738-85-5
1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

2: hydrogenchloride; ammonium chloride / iron / ethanol; water; tert-butyl methyl ether / 5 h / 50 - 70 °C

3: 2 h / 80 °C

4: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 60 - 70 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; potassium carbonate; ammonium chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); iron; In tetrahydrofuran; ethanol; tert-butyl methyl ether; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 1287738-85-5
1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

2: hydrogenchloride; ammonium chloride / iron / ethanol; water; tert-butyl methyl ether / 5 h / 50 - 70 °C

3: 2 h / 80 °C

4: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 60 - 70 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; potassium carbonate; ammonium chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); iron; In tetrahydrofuran; ethanol; tert-butyl methyl ether; water; N,N-dimethyl-formamide; mineral oil;