3-CHLORO-5,6-METHYLENEDIOXYBENZOTHIOPHENE-2-CARBONYL CHLORIDE

Base Information

• Chemical Name: 3-CHLORO-5,6-METHYLENEDIOXYBENZOTHIOPHENE-2-CARBONYL CHLORIDE
• CAS No.: 137278-46-7
• Molecular Formula: C₁₀H₄Cl₂O₃S
• Molecular Weight: 275.112
• Mol file: 137278-46-7.mol

Synonyms:3-chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride

Chemical Property of 3-CHLORO-5,6-METHYLENEDIOXYBENZOTHIOPHENE-2-CARBONYL CHLORIDE

Chemical Property:

• Melting Point: 205-207°C
• Boiling Point: 53.3～54.0℃

Purity/Quality:

3-Chloro-5,6-methylenedioxybenzothiophene-2-carbonylchloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CHLORO-5,6-METHYLENEDIOXYBENZOTHIOPHENE-2-CARBONYL CHLORIDE

There total 2 articles about 3-CHLORO-5,6-METHYLENEDIOXYBENZOTHIOPHENE-2-CARBONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3,4-(methylenedioxy)cinnamic acid (2373-80-0,38489-76-8) → 3-benzo[1,3]dioxol-5-yl-acryloyl chloride (96249-87-5,26930-49-4) + 3-chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride (137278-46-7)

Guidance literature:

With pyridine; thionyl chloride; In N,N-dimethyl-formamide; Yields of byproduct given; 1.) reflux, 4 h, 2.) 140-150 deg C, 1 h;

DOI:10.1007/BF00824304

Reference yield:

3,4-methylenedioxy-trans-cinnamic acid (2373-80-0,38489-76-8) → 3-chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride (137278-46-7)

Guidance literature:

With pyridine; thionyl chloride; In chlorobenzene;

DOI:10.1016/S0960-894X(03)00233-6

Reference yield: 93.0%

3-chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride (137278-46-7) + edaravone (89-25-8) → (7-chlorothieno[2,3-f][1,3]benzodioxol-6-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

Guidance literature:

With calcium hydroxide; In 1,4-dioxane; for 3h; Heating;

DOI:10.3390/12010060

upstream raw materials:

3,4-(methylenedioxy)cinnamic acid

3,4-methylenedioxy-trans-cinnamic acid

Downstream raw materials:

3-chloro-5,6-methylenedioxy-N-phenylbenzothiophene-2-carboxamide

5,6-bis-(biphenyl-2-ylmethoxy)-3-chloro-benzo[b]thiophene-2-carbaldehyde

5,6-bis-(biphenyl-4-ylmethoxy)-3-chloro-benzo[b]thiophene-2-carbaldehyde

5,6-bis-(biphenyl-3-ylmethoxy)-3-chloro-benzo[b]thiophene-2-carbaldehyde