N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

Base Information

Chemical Name:N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine
CAS No.:1350649-30-7
Molecular Formula:C₂₅H₁₉ClFN₅O
Molecular Weight:459.91
Hs Code.:

Synonyms:N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Chemical Property of N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Technology Process of N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

There total 11 articles about N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350648-20-2
7-iodo-1H-pyrazolo[4,3-b]pyridine

: 1350648-22-4
2-(5-chloro-2-fluorophenyl)pyridin-4-amine

: 824-94-2
p-methoxybenzyl chloride

: 1350645-25-8
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

: 1350649-30-7
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: 7-iodo-1H-pyrazolo[4,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

2-(5-chloro-2-fluorophenyl)pyridin-4-amine; With sodium t-butanolate; palladium diacetate; In toluene; at 100 ℃; Product distribution / selectivity;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1350649-30-7
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

1.2: 0.67 h / -78 °C

2.1: hydrazine hydrate / butan-1-ol / 2 h / 105 °C

3.1: sodium nitrite; acetic acid / water / 25 h / 0 - 20 °C

3.2: 3 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

4.2: 0.5 h / Cooling with ice

5.1: sodium t-butanolate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / Microwave irradiation; Inert atmosphere; Heating

With n-butyllithium; sodium hydride; hydrazine hydrate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; diisopropylamine; sodium t-butanolate; sodium nitrite; palladium diacetate; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1350649-30-7
N-(2-(5-chloro-2-fluorophenyl)pyridin-4-yl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / butan-1-ol / 2 h / 105 °C

2.1: sodium nitrite; acetic acid / water / 25 h / 0 - 20 °C

2.2: 3 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h / Cooling with ice

4.1: sodium t-butanolate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / palladium diacetate / toluene / Microwave irradiation; Inert atmosphere; Heating

With sodium hydride; hydrazine hydrate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; sodium nitrite; palladium diacetate; In water; N,N-dimethyl-formamide; toluene; butan-1-ol;