methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

Base Information

Chemical Name:methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate
CAS No.:609345-95-1
Molecular Formula:C₃₃H₃₄ClN₇O₆
Molecular Weight:660.129
Hs Code.:

methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

Synonyms:methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

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Chemical Property of methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

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Technology Process of methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

There total 6 articles about methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: benzyl amino[4-(aminomethyl)phenyl]methylenecarbamate

: 602280-55-7
[6-[3-amino-5-(methoxycarbonyl)phenyl]-5-chloro-3-(isopropylamino)-2-oxopyrazin-1(2H)-yl]acetic acid

: 609345-95-1
methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

Guidance literature:: With 4-methyl-morpholine; polymer-bound carbodiimide reagent; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm030131l

Reference yield:

: 1955-46-0
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

: 609345-95-1
methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / BH₃*THF / tetrahydrofuran / -10 - 64 °C

2.1: 78 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.75 h / -78 °C

3.1: CH₂Cl₂ / 16 h / 20 °C

3.2: chlorobenzene / 16 h / 80 °C

4.1: 46 percent / ethyl acetate / 16 h / 55 °C

5.1: 76 percent / H₂; aq. HCl / Pd/C / methanol / 16 h / 20 °C

6.1: 79 percent / 1-hydroxybenzotriazole; N-methylmorpholine; polymer-bound carbodiimide reagent / CH₂Cl₂; dimethylformamide / 3 h

With 4-methyl-morpholine; hydrogenchloride; borane-THF; oxalyl dichloride; polymer-bound carbodiimide reagent; hydrogen; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm030131l

Reference yield:

: 53732-08-4
3-hydroxymethyl-5-nitrobenzoic acid methyl ester

: 609345-95-1
methyl 3-amino-5-[1-(2-{[4-((Z)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.75 h / -78 °C

2.1: CH₂Cl₂ / 16 h / 20 °C

2.2: chlorobenzene / 16 h / 80 °C

3.1: 46 percent / ethyl acetate / 16 h / 55 °C

4.1: 76 percent / H₂; aq. HCl / Pd/C / methanol / 16 h / 20 °C

5.1: 79 percent / 1-hydroxybenzotriazole; N-methylmorpholine; polymer-bound carbodiimide reagent / CH₂Cl₂; dimethylformamide / 3 h

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; polymer-bound carbodiimide reagent; hydrogen; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm030131l