Technology Process of [6-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-carbamic acid benzyl ester
There total 6 articles about [6-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-carbamic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(6-oxo-4,5,6,7-tetrahydrobenzothiazol-2-yl)-carbamic acid benzyl ester; cis-2,6-dimethylmorpholine;
acetic acid;
In
1,2-dichloro-ethane;
at 120 ℃;
for 0.25h;
Inert atmosphere;
Microwave reactor;
With
sodium cyanoborohydride;
In
1,2-dichloro-ethane;
for 1h;
With
sodium carbonate;
In
1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / cyclohexane
2.1: sulfur / methanol / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 4 - 20 °C / Inert atmosphere
4.1: water / trifluoroacetic acid / 2.5 h / 65 °C
5.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 120 °C / Inert atmosphere; Microwave reactor
5.2: 1 h
With
sulfur; water; N-ethyl-N,N-diisopropylamine;
toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; cyclohexane; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfur / methanol / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 4 - 20 °C / Inert atmosphere
3.1: water / trifluoroacetic acid / 2.5 h / 65 °C
4.1: acetic acid / 1,2-dichloro-ethane / 0.25 h / 120 °C / Inert atmosphere; Microwave reactor
4.2: 1 h
With
sulfur; water; N-ethyl-N,N-diisopropylamine;
acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane;
