4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

Base Information

Chemical Name:4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide
CAS No.:126645-68-9
Molecular Formula:C₂₁H₂₆ClN₃O₃
Molecular Weight:403.909
Hs Code.:

Synonyms:4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

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Chemical Property of 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

Chemical Property:

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Technology Process of 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

There total 7 articles about 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40987-25-5,186293-54-9
N-benzyl-2-chloromethylmorpholine

: 126645-68-9
4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / potassium iodide / dimethylsulfoxide / 5 h / 120 °C

2: 81 percent / 28percent ammonia water, H₂ / Raney nickel / ethanol / Ambient temperature

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With ammonium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; nickel; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00167a020

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 126645-68-9
4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) concd. H₂SO₄ / 1.) RT, 3 h, 2.) 150 deg C, 1 h

2: 93 percent / potassium iodide / dimethylsulfoxide / 5 h / 120 °C

3: 81 percent / 28percent ammonia water, H₂ / Raney nickel / ethanol / Ambient temperature

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With ammonium hydroxide; sulfuric acid; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; nickel; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00167a020

Reference yield:

: 112887-43-1
2-(2-hydroxyethyl)-4-benzylmorpholine

: 126645-68-9
4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 20 h / Ambient temperature

2: 13.2 g / 85percent hydrazine monohydrate / ethanol / 1.5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00167a020