Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Base Information

Chemical Name:Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester
CAS No.:213816-90-1
Molecular Formula:C₂₁H₃₀O₆
Molecular Weight:378.466
Hs Code.:

Synonyms:Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Suppliers and Price of Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

There total 20 articles about Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 213816-67-2
((1R,2R,5S)-2-(benzyloxy)methyl-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)-3-oxocyclopentyl)methyl acetate

: 213816-90-1
Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃;
DOI:10.1016/S0040-4039(98)01385-9

Reference yield:

: 213816-86-5
(2R,3R,4S)-4-Acetyl-2-benzyloxymethyl-3-hydroxymethyl-2-methyl-cyclopentanone

: 213816-90-1
Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / 5 h / 20 °C

2: 90 percent / trimethylsilyl triflate / CH₂Cl₂ / 18 h / -40 °C

3: 98 percent / NaBH₄ / methanol / 0.25 h / 0 °C

With pyridine; sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(02)01474-6

Reference yield:

: 213816-83-2
Acetic acid (1S,2S,4R,5R,6R)-5-benzyloxymethyl-4-hydroxy-6-hydroxymethyl-5-methyl-bicyclo[2.2.1]hept-2-yl ester

: 213816-90-1
Acetic acid (1R,2R,5S)-2-benzyloxymethyl-3-hydroxy-2-methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / imidazole / dimethylformamide / 5 h / 20 °C

2: 100 percent / K₂CO₃ / methanol / 2 h / 20 °C

3: 90 percent / pyridinium chlorochromate; molecular sieves 4 Amgstroem / CH₂Cl₂ / 2 h / 20 °C

4: 86 percent / NaH; 15-crown-5 / toluene / 1 h / 20 °C

5: 97 percent / CH₃COOH / H₂O / 5 h / 20 °C

6: 100 percent / pyridine / 5 h / 20 °C

7: 90 percent / trimethylsilyl triflate / CH₂Cl₂ / 18 h / -40 °C

8: 98 percent / NaBH₄ / methanol / 0.25 h / 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; 15-crown-5; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sodium hydride; potassium carbonate; acetic acid; pyridinium chlorochromate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)01474-6