3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid

Base Information

Chemical Name:3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid
CAS No.:1000850-94-1
Molecular Formula:C₂₁H₁₈F₄N₂O₅
Molecular Weight:454.378
Hs Code.:

Synonyms:3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid

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Chemical Property of 3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid

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Technology Process of 3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid

There total 1 articles about 3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1000850-93-0
diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

: 1000850-94-1
3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid

Guidance literature:: diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate; With sodium hydroxide; water; In ethanol; at 20 ℃; for 48h;

With hydrogenchloride; In water; pH=4;