diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

Base Information

Chemical Name:diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate
CAS No.:1000850-93-0
Molecular Formula:C₂₆H₂₆F₄N₂O₇
Molecular Weight:554.495
Hs Code.:

Synonyms:diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

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Chemical Property of diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

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Technology Process of diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

There total 1 articles about diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1000850-92-9
4-(6,7-dimethoxyquinolin-4-yloxy)-N-(1-ethoxy-2,2,2-trifluoroethyl)-3-fluoroaniline

: 105-53-3
diethyl malonate

: 1000850-93-0
diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 2h; Heating / reflux;

Reference yield: 35.0%

: 1000850-93-0
diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate

: 1000850-94-1
3-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-4,4,4-trifluorobutanoic acid

Guidance literature:: diethyl 2-(1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylamino)-2,2,2-trifluoroethyl)malonate; With sodium hydroxide; water; In ethanol; at 20 ℃; for 48h;

With hydrogenchloride; In water; pH=4;