tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate
CAS No.:1018910-10-5
Molecular Formula:C₄₃H₅₉FN₄O₇
Molecular Weight:762.962
Hs Code.:

tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Synonyms:tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

There total 9 articles about tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1018910-09-2
tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-{2-[2-(3-fluoro-phenyl)-ethylamino]-ethoxy}-pyrrolidine-1-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 1018910-10-5
tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Guidance literature:: With sodium hydroxide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm100947x

Reference yield:

: (+/-)-trans-tert-butyl 3-{{6-[benzyl(tert-butoxycarbonyl)amino]-4-methyl-pyridin-2-yl}methyl}-4-hydroxy-pyrrolidine-1-carboxylate

: 1018910-10-5
tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

2.1: methanol; sodium hydroxide; water / 20 °C

2.2: pH 7

3.1: dmap; triethylamine / dichloromethane / 7 h / 0 - 20 °C

4.1: methanol; water

5.1: methanol; water; sodium carbonate / 14 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

6.2: 3 h / 0 - 20 °C

7.1: ozone / dichloromethane / 0.5 h / -78 °C

7.2: 0.75 h / -78 - 20 °C

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 14 h / 20 °C / Molecular sieves 3 ?

9.1: sodium hydroxide / dichloromethane; water / 24 h / 20 °C

With methanol; dmap; sodium hydroxide; di-isopropyl azodicarboxylate; water; sodium tris(acetoxy)borohydride; sodium hydride; sodium carbonate; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1018910-08-1
tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-oxo-ethoxy)-pyrrolidine-1-carboxylate

: 1018910-10-5
tert-butyl (3S,4S)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 14 h / 20 °C / Molecular sieves 3 ?

2: sodium hydroxide / dichloromethane; water / 24 h / 20 °C

With sodium hydroxide; sodium tris(acetoxy)borohydride; In dichloromethane; water; 1,2-dichloro-ethane;