(S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

Base Information

Chemical Name:(S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile
CAS No.:374119-18-3
Molecular Formula:C₁₉H₂₄N₂O₅
Molecular Weight:360.41
Hs Code.:

Synonyms:(S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

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Chemical Property of (S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

Chemical Property:

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Technology Process of (S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

There total 6 articles about (S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 225122-57-6
O-[[3-(allyloxycarbonyl)phenyl]methyl]-N-(t-butoxycarbonyl)-L-serinamide

: 374119-18-3
(S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

Guidance literature:: With pyridine; oxalyl dichloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.75h;
DOI:10.1021/jm010206q

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 374119-18-3
(S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.58 h / 0 - 20 °C

1.2: dimethylformamide / 0.5 h / 0 - 20 °C

2.1: N-methylmorpholine / CH₂Cl₂ / 0.25 h

3.1: NH₃(g) / CH₂Cl₂ / 0.5 h / 20 °C

4.1: oxalyl chloride; pyridine / dimethylformamide / 0.75 h / 0 °C

With 4-methyl-morpholine; pyridine; oxalyl dichloride; ammonia; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010206q

Reference yield:

: 31719-77-4
3-chloromethylbenzoic acid

: 374119-18-3
(S)-2-(tert-butoxycarbonylamino)-3-(3-allyloxycarbonylphenyl)methoxypropionitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / acetone / 2 h / Heating

1.2: 76 percent / NaI / acetone / 6.5 h

2.1: NaH / dimethylformamide / 0.58 h / 0 - 20 °C

2.2: dimethylformamide / 0.5 h / 0 - 20 °C

3.1: N-methylmorpholine / CH₂Cl₂ / 0.25 h

4.1: NH₃(g) / CH₂Cl₂ / 0.5 h / 20 °C

5.1: oxalyl chloride; pyridine / dimethylformamide / 0.75 h / 0 °C

With 4-methyl-morpholine; pyridine; oxalyl dichloride; ammonia; sodium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm010206q