(4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

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Chemical Name:(4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one
CAS No.:112654-55-4
Molecular Formula:C₁₉H₁₇NO₃S
Molecular Weight:339.415
Hs Code.:

Synonyms:(4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

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Chemical Property of (4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

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Technology Process of (4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

There total 5 articles about (4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 112654-54-3
Acetic acid benzoylamino-[(E)-3-(4-methoxy-phenyl)-allylsulfanylcarbonyl]-methyl ester

: 112654-55-4
(4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

Guidance literature:: In chlorobenzene; at 145 - 150 ℃; for 17h;
DOI:10.1021/jo00239a031

Reference yield:

: 19791-95-8,19791-97-0,16555-77-4
α-hydroxyhippuric acid

: 112654-55-4
(4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature

2: 94 percent / pyridine / CH₂Cl₂ / 0.33 h

3: 60 percent / chlorobenzene / 17 h / 145 - 150 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/jo00239a031

Reference yield:

: 94607-41-7
(E)-1-(4-methoxyphenyl)-3-chloropropene

: 112654-55-4
(4R,4aR,7aR)-4-(4-Methoxy-phenyl)-2-phenyl-4a,7a-dihydro-4H,5H-thieno[3,4-d][1,3]oxazin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium iodide, thiourea, 2.) ethylenediamine / 1.) ethanol, reflux, 2 h, 2.) reflux, 30 min

2: 48 percent / dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature

3: 94 percent / pyridine / CH₂Cl₂ / 0.33 h

4: 60 percent / chlorobenzene / 17 h / 145 - 150 °C

With pyridine; dmap; ethylenediamine; thiourea; dicyclohexyl-carbodiimide; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/jo00239a031