5-Hydroxyquinoxaline

Base Information

• Chemical Name: 5-Hydroxyquinoxaline
• CAS No.: 17056-99-4
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 17056-99-4.mol

Synonyms:5-Quinoxalinol;8-Quinoxalinol;

Chemical Property of 5-Hydroxyquinoxaline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 100-102℃
• Refractive Index: 1.705
• Boiling Point: 319.993 °C at 760 mmHg
• Flash Point: 147.327 °C
• PSA: 46.01000
• Density: 1.348 g/cm³
• LogP: 1.33540
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Hydroxyquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Hydroxyquinoxaline is used in the synthesis of potent gp120-CD4 inhibitors, useful in HIV treatment. Also in the design and synthesis of para-quinone-based inhibitors acting on CdC25B.

Technology Process of 5-Hydroxyquinoxaline

There total 10 articles about 5-Hydroxyquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2,3-diaminophenol (59649-56-8) + glyoxal sodium bisulfite (517-21-5) → 5-hydroxyquinoxaline (17056-99-4)

Guidance literature:

With sodium acetate; acetic acid; In water; at 60 ℃; for 1h;

DOI:10.1039/c5cc06095h

Reference yield: 45.0%

2,3-diethynylquinoxaline (91-19-0) → 5-hydroxyquinoxaline (17056-99-4) + cis-5,6-Dihydroquinoxaline-5,6-diol (112259-29-7) + 2-hydroxyquinoxaline (1196-57-2,144499-26-3)

Guidance literature:

With Pseudomonas putida;

DOI:10.1039/c39870001722

Reference yield: 15.0%

2,3-diethynylquinoxaline (91-19-0) → 5-hydroxyquinoxaline (17056-99-4)

Guidance literature:

With acid; UV-irradiation;

DOI:10.1023/B:RUGC.0000030402.66220.55

upstream raw materials:

2,3-diaminophenol

glyoxal sodium bisulfite

5-methoxyquinoxaline

2,3-diethynylquinoxaline

Downstream raw materials:

C₂₃H₂₄N₄O₃

phenazin-1-yl acetate

Phenazin

Refernces

• 1、 Thinnes,Tumber,Yapp,Scozzafava,Yeh,Chan,Tran,Hsu,Tarhonskaya,Walport,Wilkins,Martinez,Müller,Pugh,Ratcliffe,Brennan,Kawamura,Schofield. "Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases". supporting information. p. 15458 - 15461. Retrieved 2015/10/20.
• 2、 Rtishchev,Selitrennikov. "Phototransformations of 6-X-5-nitroquinoxalines". . p. 428 - 437. Retrieved 2007/10/03.