(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Base Information

Chemical Name:(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene
CAS No.:138505-83-6
Molecular Formula:C₃₄H₅₂O₃Si₂
Molecular Weight:564.956
Hs Code.:

(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Synonyms:(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Suppliers and Price of (1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

There total 10 articles about (1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 138505-82-5
(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

: 138505-83-6
(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Guidance literature:: In dichloromethane; for 18h;
DOI:10.1021/jm00096a015

Reference yield:

: 138505-81-4
ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dihydroxy-2-methylnaphthalene-1-carboxylate

: 138505-83-6
(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 16 h

2: LiAlH₄ / diethyl ether / 1 h

3: 86 percent / CH₂Cl₂ / 18 h

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015

Reference yield:

: 138505-80-3
ethyl (1S,2S,4aR,6R,8S,8aS)-6-acetoxy-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene-1-carboxylate

: 138505-83-6
(1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / sodium ethoxide / ethanol / 0.5 h

2: imidazole / dimethylformamide / 16 h

3: LiAlH₄ / diethyl ether / 1 h

4: 86 percent / CH₂Cl₂ / 18 h

With 1H-imidazole; lithium aluminium tetrahydride; sodium ethanolate; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015