benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

Base Information

Chemical Name:benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate
CAS No.:149606-72-4
Molecular Formula:C₂₀H₂₉NO₅
Molecular Weight:363.454
Hs Code.:

Synonyms:benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

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Technology Process of benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

There total 3 articles about benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 149606-71-3
benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxypropanoate

: 74-88-4
methyl iodide

: 149606-72-4
benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1248/cpb.43.1706

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 149606-72-4
benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / tetrahydrofuran

2: 65 percent / NaH / dimethylformamide / 0 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.1706

Reference yield:

: lithium salt of benzyl acetate

: 149606-72-4
benzyl (3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / tetrahydrofuran

2: 65 percent / NaH / dimethylformamide / 0 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.1706