2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

Base Information

Chemical Name:2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid
CAS No.:1428548-28-0
Molecular Formula:C₂₃H₂₂N₄O₇
Molecular Weight:466.45
Hs Code.:

Synonyms:2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

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Chemical Property of 2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

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Technology Process of 2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

There total 7 articles about 2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1428548-51-9
methyl 2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetate

: 1428548-28-0
2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

Guidance literature:: With water; potassium hydroxide; at 50 ℃; for 0.5h;

Reference yield:

: 1428548-49-5
N-[bis(4-methoxyphenyl)methyl]-2-formyl-4-hydroxypyrimidine-5-carboxamide

: 1428548-28-0
2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium chlorite; sodium hydrogenphosphate dodecahydrate / tert-butyl alcohol / 2 h / 20 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

3: water; potassium hydroxide / 0.5 h / 50 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1428548-40-6
ethyl 2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylate

: 1428548-28-0
2-[5-{[bis(4-methoxyphenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxamido]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: water; potassium hydroxide / 1 h / 70 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; N,N-dimethyl-formamide / 20 °C

3: palladium on activated charcoal; ammonium formate / methanol / Reflux

4: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5: sodium chlorite; sodium hydrogenphosphate dodecahydrate / tert-butyl alcohol / 2 h / 20 °C

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

7: water; potassium hydroxide / 0.5 h / 50 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; palladium on activated charcoal; water; ammonium formate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;