1-(4-(2-Fluoroethoxy)phenyl)piperazine

Base Information

Chemical Name:1-(4-(2-Fluoroethoxy)phenyl)piperazine
CAS No.:913734-75-5
Molecular Formula:C₁₂H₁₇FN₂O
Molecular Weight:224.278
Hs Code.:
European Community (EC) Number:849-508-1
Nikkaji Number:J3.529.821E

Synonyms:1-(4-(2-fluoroethoxy)phenyl)piperazine;1-[4-(2-fluoroethoxy)phenyl]piperazine;913734-75-5;SCHEMBL3117428;JLDPFWAZFIUMLR-UHFFFAOYSA-N;AKOS019266155;EN300-7541823

Suppliers and Price of 1-(4-(2-Fluoroethoxy)phenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-(2-Fluoroethoxy)phenyl)piperazine

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:224.13249133
Heavy Atom Count:16
Complexity:190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1)C2=CC=C(C=C2)OCCF

Technology Process of 1-(4-(2-Fluoroethoxy)phenyl)piperazine

There total 7 articles about 1-(4-(2-Fluoroethoxy)phenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 913734-71-1
tert-butyl 4-(4-(2-fluoroethoxy)phenyl)piperazine-1-carboxylate

: 913734-75-5
1-(4-(2-fluoroethoxy)phenyl)piperazine

Guidance literature:: tert-butyl 4-(4-(2-fluoroethoxy)phenyl)piperazine-1-carboxylate; With trifluoroacetic acid; at 20 ℃; for 2h;

With ammonium hydroxide; In diethyl ether; water;
DOI:10.1002/jlcr.1589

Reference yield: 60.0%

: 4-(4-(2-fluoroethoxy)phenyl)piperazine-1-carboxylic acid t-butyl ester

: 913734-75-5
1-(4-(2-fluoroethoxy)phenyl)piperazine

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 0.25h;
DOI:10.1002/jlcr.1026

Reference yield:

: 158985-25-2
tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

: 913734-75-5
1-(4-(2-fluoroethoxy)phenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 105 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With potassium carbonate; trifluoroacetic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c5md00079c