1-Acetyl-4-(4-hydroxyphenyl)piperazine

Base Information

Chemical Name:1-Acetyl-4-(4-hydroxyphenyl)piperazine
CAS No.:67914-60-7
Molecular Formula:C₁₂H₁₆N₂O₂
Molecular Weight:220.271
Hs Code.:29214910
European Community (EC) Number:267-744-8
UNII:YH9GD5K5NY
DSSTox Substance ID:DTXSID3057804
Nikkaji Number:J287.743K
Wikidata:Q27455472
ChEMBL ID:CHEMBL202608
Mol file:67914-60-7.mol

Synonyms:1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone

Suppliers and Price of 1-Acetyl-4-(4-hydroxyphenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Acetyl-4-(4-hydroxyphenyl)piperazine
1g
$ 55.00

TCI Chemical
1-Acetyl-4-(4-hydroxyphenyl)piperazine >98.0%(GC)(T)
250g
$ 114.00

TCI Chemical
1-Acetyl-4-(4-hydroxyphenyl)piperazine >98.0%(GC)(T)
25g
$ 20.00

Sigma-Aldrich
1-Acetyl-4-(4-hydroxyphenyl)piperazine 98%
25g
$ 29.00

Medical Isotopes, Inc.
1-Acetyl-4-(4-hydroxyphenyl)piperazine
5 g
$ 1880.00

Matrix Scientific
1-Acetyl-4-(4-hydroxyphenyl)piperazine 95%+
5g
$ 323.00

Matrix Scientific
1-Acetyl-4-(4-hydroxyphenyl)piperazine 95%+
1g
$ 101.00

Matrix Scientific
1-Acetyl-4-(4-hydroxyphenyl)piperazine 95%+
2.500g
$ 215.00

Frontier Specialty Chemicals
1-Acetyl-4-(4-hydroxyphenyl)piperazine 98%
25g
$ 34.00

Chem-Impex
1-Acetyl-4-(4-hydroxyphenyl)piperazine,99%(Assaybytitration,HPLC) 99%(Assaybytitration,HPLC)
5KG
$ 1848.00

Total 165 raw suppliers

Chemical Property of 1-Acetyl-4-(4-hydroxyphenyl)piperazine

Chemical Property:

Appearance/Colour:Off-white solid
Vapor Pressure:5.91E-09mmHg at 25°C
Melting Point:180-185 °C(lit.)
Refractive Index:1.584
Boiling Point:456.5 °C at 760 mmHg
PKA:12.18±0.30(Predicted)
Flash Point:229.9 °C
PSA：43.78000
Density:1.207 g/cm³
LogP:1.06360
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
Water Solubility.:4.3 g/L (20 ºC)
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:220.121177757
Heavy Atom Count:16
Complexity:241

Purity/Quality:

99% ^*data from raw suppliers

1-Acetyl-4-(4-hydroxyphenyl)piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xi,Xn
Statements: 36/37/38-22
Safety Statements: 26-36-36/37/39-22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CCN(CC1)C2=CC=C(C=C2)O
Uses 1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs.

Technology Process of 1-Acetyl-4-(4-hydroxyphenyl)piperazine

There total 11 articles about 1-Acetyl-4-(4-hydroxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 133345-21-8
1-(4-Acetoxyphenyl)-4-acetylpiperazine

: 67914-60-7,89929-31-7
N-acetyl-N'-(4-hydroxyphenyl)piperazine

Guidance literature:: With water; potassium hydrogencarbonate; In methanol; Ambient temperature;
DOI:10.1002/ardp.19923251102

Reference yield: 54.0%

: 56621-48-8
1-(4-hydroxyphenyl)piperazine

: 108-24-7
acetic anhydride

: 67914-60-7,89929-31-7
N-acetyl-N'-(4-hydroxyphenyl)piperazine

Guidance literature:: 1-(4-hydroxyphenyl)piperazine; acetic anhydride; With pyridine; at 0 - 20 ℃; for 3.08333h;

With methanol; water; potassium carbonate; for 1.5h;

With hydrogenchloride; water; In dichloromethane; pH=3;

Reference yield:

: 1336-21-6
ammonium hydroxide

: 1972-28-7,218603-74-8
diethylazodicarboxylate

: 67914-60-7,89929-31-7
N-acetyl-N'-(4-hydroxyphenyl)piperazine

Guidance literature:: With sodium hydroxide; oxalic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;