4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

Base Information

Chemical Name:4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene
CAS No.:944334-15-0
Molecular Formula:C₁₆H₁₉BrF₂O₂Si
Molecular Weight:389.312
Hs Code.:

Synonyms:4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

Suppliers and Price of 4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

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Technology Process of 4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

There total 2 articles about 4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 944334-04-7
5-bromo-2-difluoromethoxyphenol

: 192315-00-7
1-cyclopropyl-3-(trimethylsilyl)prop-2-yn-1-ol

: 944334-15-0
4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 5 - 20 ℃; for 3.5h;

Reference yield:

: 680184-55-8
4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene

: 944334-15-0
4-bromo-2-(1-cyclopropyl-3-trimethylsilyl-2-propynyloxy)-1-difluoromethoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; methanol; water / 5 h / Heating / reflux

2: triphenylphosphine; diethylazodicarboxylate / toluene / 3.5 h / 5 - 20 °C

With hydrogenchloride; methanol; water; triphenylphosphine; diethylazodicarboxylate; In toluene; 2: Mitsunobu reaction;