trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

Base Information

Chemical Name:trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide
CAS No.:1354933-96-2
Molecular Formula:C₂₀H₃₂N₄O₃S
Molecular Weight:408.565
Hs Code.:

Synonyms:trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

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Chemical Property of trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

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Technology Process of trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

There total 3 articles about trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: trans-4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexylamine trihydrochloride

: 124-63-0
methanesulfonyl chloride

: 1354933-96-2
trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

Guidance literature:: trans-4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexylamine trihydrochloride; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 18h;

With sodium hydroxide; In dichloromethane; water; Cooling with ice;

Reference yield:

: 209160-83-8
7-piperazin-1-yl-furo[2,3-c]pyridine

: 1354933-96-2
trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 24 h / 20 °C

2.1: triethylamine / dichloromethane; methanol / 0.5 h / 20 °C

2.2: 4 h / 20 °C

2.3: Cooling with ice

3.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane / 3.5 h / 20 °C

4.1: triethylamine / dichloromethane / 18 h / 20 °C

4.2: Cooling with ice

With hydrogenchloride; water; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1354934-84-1
7-(piperazin-1-yl)-2,3-dihydro-furo[2,3-c]pyridine

: 1354933-96-2
trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane; methanol / 0.5 h / 20 °C

1.2: 4 h / 20 °C

1.3: Cooling with ice

2.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane / 3.5 h / 20 °C

3.1: triethylamine / dichloromethane / 18 h / 20 °C

3.2: Cooling with ice

With hydrogenchloride; water; triethylamine; In 1,4-dioxane; methanol; dichloromethane;