{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate

Base Information

• Chemical Name: {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate
• CAS No.: 1258973-72-6
• Molecular Formula: C₂HF₃O₂*C₂₄H₃₁N₅O₆
• Molecular Weight: 599.564
• Mol file: 1258973-72-6.mol

Synonyms:{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate

Chemical Property of {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate

There total 2 articles about {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-70-4) + trifluoroacetic acid (76-05-1) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate (1258973-72-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/cmdc.201000308

Reference yield:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide (131308-91-3) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate (1258973-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: dichloromethane / 1 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201000308

Reference yield: 88.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate (1258973-72-6) + C32H35N3O6S → (3R,4R)-(9H-fluoren-9-yl)methyl 3-((S)-2-((((S)-1-(2-(5-acetamido-2-methoxybenzoyl)hydrazinyl)-6-(((benzyloxy)carbonyl)amino)-1-oxohexan-2-yl)oxy)carbonyl)pyrrolidin-1-yl)-4-(4-methylphenylsulfonamido)piperidine-1-carboxylate

Guidance literature:

C₃₂H₃₅N₃O₆S; With 1-hydroxy-7-aza-benzotriazole; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate; In N,N-dimethyl-formamide; at 0 - 20 ℃; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.05.018

upstream raw materials:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

trifluoroacetic acid

Downstream raw materials:

C₅₉H₈₀N₈O₁₄

C₆₆H₇₈N₁₀O₁₆