{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

Base Information

• Chemical Name: {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester
• CAS No.: 1258973-70-4
• Molecular Formula: C₂₉H₃₉N₅O₈
• Molecular Weight: 585.657

Synonyms:{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

Chemical Property of {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

There total 1 articles about {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide (131308-91-3) + N-Boc-N-Z-K-OH (34279-80-6) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-70-4)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/cmdc.201000308

Reference yield: 96.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-70-4) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-74-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1002/cmdc.201000308

Reference yield: 88.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-70-4) + trifluoroacetic acid (76-05-1) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-amino-6-oxohexyl}carbamic acid benzyl ester trifluoroacetate (1258973-72-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/cmdc.201000308

upstream raw materials:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide

N-Boc-N-Z-K-OH

Downstream raw materials:

C₆₆H₇₈N₁₀O₁₆

C₆₀H₈₂N₁₀O₁₆

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

C₅₉H₈₀N₈O₁₄

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