Technology Process of 5-(3,4-dichlorophenyl)-2,5-ethano-8-(difluoromethoxy)-2,3,4,5-tetrahydro-1H-benzo[c]azepine, L-tartrate salt
There total 8 articles about 5-(3,4-dichlorophenyl)-2,5-ethano-8-(difluoromethoxy)-2,3,4,5-tetrahydro-1H-benzo[c]azepine, L-tartrate salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 19 h / 20 °C
1.2: 0.25 h
2.1: hydrogenchloride / water / 1.08 h / 0 - 20 °C
2.2: 0 °C
3.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h
3.2: 3 h / 0 - 20 °C
4.1: trifluorormethanesulfonic acid / dichloromethane / 2 h / 0 - 20 °C
5.1: hydrogen bromide / water; acetic acid / 9 h / 135 °C
5.2: 8.5 - 10 h
6.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C
7.1: acetonitrile; water
With
hydrogenchloride; trifluorormethanesulfonic acid; hydrogen bromide; isopropylmagnesium bromide; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid;
In
tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h
1.2: 3 h / 0 - 20 °C
2.1: trifluorormethanesulfonic acid / dichloromethane / 2 h / 0 - 20 °C
3.1: hydrogen bromide / water; acetic acid / 9 h / 135 °C
3.2: 8.5 - 10 h
4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C
5.1: acetonitrile; water
With
trifluorormethanesulfonic acid; hydrogen bromide; isopropylmagnesium bromide; caesium carbonate;
In
tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
