(S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

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Chemical Name:(S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide
CAS No.:1315585-50-2
Molecular Formula:C₂₆H₂₈F₂N₈O₂S
Molecular Weight:554.624
Hs Code.:

Synonyms:(S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

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Chemical Property of (S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

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Technology Process of (S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

There total 5 articles about (S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1315590-94-3
2-chloro-N-(4-(4-(5-cyclobutyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)acetamide

: 623583-10-8
(S)-(4,4-difluoropyrrolidin-2-yl)methanol hydrochloride

: 1315585-50-2
(S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide; at 45 ℃; for 5h;

Reference yield:

: 326827-21-8
5-cyclobutyl-3-amino-1H-pyrazole

: 1315585-50-2
(S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

3.1: tetrahydrofuran / 1.5 h / 0 - 20 °C

3.2: 0.08 h

4.1: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 45 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1001353-97-4
2-chloro-N-(5-cyclobutyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine

: 1315585-50-2
(S)-N-(4-(4-(5-cyclobuty1-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)-2-(4.4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 0 - 20 °C

2.2: 0.08 h

3.1: potassium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 45 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;