3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1379669-77-8
Molecular Formula:C₂₀H₁₅FN₆O
Molecular Weight:374.377
Hs Code.:

Synonyms:3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

There total 6 articles about 3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379670-83-3
N-hydroxy-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamidine

: 331-25-9
(3-fluorophenyl)acetic acid

: 1379669-77-8
3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: (3-fluorophenyl)acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

N-hydroxy-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 1093676-98-2
3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

: 1379669-77-8
3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1.5 h / 20 - 25 °C / Inert atmosphere

2.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 1 h / 70 °C / Inert atmosphere

3.1: potassium hydroxide; hydroxylamine hydrochloride / N,N-dimethyl-formamide; methanol / 84 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 0.33 h / 20 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; zinc; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1379669-77-8
3-[5-(3-fluorobenzyl)-1,2,4-oxadiazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3.5 h / 10 - 120 °C / Inert atmosphere

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1.5 h / 20 °C

3.1: pyridine / dichloromethane / 1.5 h / 20 - 25 °C / Inert atmosphere

4.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 1 h / 70 °C / Inert atmosphere

5.1: potassium hydroxide; hydroxylamine hydrochloride / N,N-dimethyl-formamide; methanol / 84 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 0.33 h / 20 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; iodine; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; zinc; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;