6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

Base Information

Chemical Name:6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one
CAS No.:1104449-81-1
Molecular Formula:C₁₈H₂₂N₂O₄S*ClH
Molecular Weight:398.911
Hs Code.:

Synonyms:6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

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Chemical Property of 6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

Chemical Property:

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Technology Process of 6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

There total 7 articles about 6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1104449-77-5
tert-butyl 4-(6-methyl-1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

: 1104449-81-1
6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm501175v

Reference yield:

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 1104449-81-1
6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 2.5 h / 138 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

3: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v

Reference yield:

: 4-hydroxy-6-methyl-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one

: 1104449-81-1
6-methyl-1-(4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v