(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide
CAS No.:1453070-37-5
Molecular Formula:C₁₅H₁₉F₆NOS
Molecular Weight:375.378
Hs Code.:

Synonyms:(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

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Chemical Property of (R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

There total 3 articles about (R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1453070-36-4
(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

: 74-88-4
methyl iodide

: 1453070-37-5
(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: (R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -60 - 20 ℃; for 3h;

Reference yield:

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 1453070-37-5
(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

3.2: 3 h / -60 - 20 °C

With titanium(IV) isopropylate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: (R)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

: 1453070-37-5
(R)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

2.2: 3 h / -60 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;