tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Base Information

Chemical Name:tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside
CAS No.:496052-66-5
Molecular Formula:C₅₈H₆₃NO₁₆Si
Molecular Weight:1058.22
Hs Code.:

Synonyms:tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

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Chemical Property of tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

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Technology Process of tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

There total 3 articles about tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: tert-butyldiphenylsilyl 2-phthalimido-3,6-di-O-benzyl-2-deoxy-β-D-dlucopyranoside

: 3068-32-4
1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside

: 496052-66-5
tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:: With silver trifluoromethanesulfonate;
DOI:10.1016/S0040-4039(02)01947-0

Reference yield: 70.0%

: tert-butyldiphenylsilyl 2-phthalimido-3,6-di-O-benzyl-2-deoxy-β-D-dlucopyranoside

: 3068-32-4
1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside

: 496052-67-6
acetic acid 6-acetoxy-5-acetoxymethyl-2-[4-benzyloxy-2-benzyloxymethyl-6-(tert-butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-3-yloxy]-2-methyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-7-yl ester

: 496052-66-5
tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:: tert-butyldiphenylsilyl 2-phthalimido-3,6-di-O-benzyl-2-deoxy-β-D-dlucopyranoside; 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside; With 2,6-di-tert-butyl-4-methylpyridine; 4 A molecular sieve; In dichloromethane; for 1.5h;

With silver trifluoromethanesulfonate; In dichloromethane; at -20 ℃; for 1h;
DOI:10.1271/bbb.66.1904

Reference yield:

: tert-butyldiphenylsilyl 2-phthalimido-3,6-di-O-benzyl-2-deoxy-β-D-dlucopyranoside

: 496052-66-5
tert-butyldiphenylsilyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h

1.2: 20 percent / AgOTf / CH₂Cl₂ / 1 h / -20 °C

2.1: 83 percent / 4 Angstroem molecular sieves; TMSOTf / CH₂Cl₂ / 0.33 h / -10 °C

With 2,6-di-tert-butyl-4-methylpyridine; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In dichloromethane;
DOI:10.1271/bbb.66.1904