(S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

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Chemical Name:(S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one
CAS No.:1367359-28-1
Molecular Formula:C₂₃H₂₆BrFN₄O₂
Molecular Weight:489.387
Hs Code.:

Synonyms:(S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

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Chemical Property of (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

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Technology Process of (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

There total 8 articles about (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-30-9
2-iodo-propane

: (S)-6-(4-bromo-2-fluorophenoxy)-2-methyl-3-(piperidin-3-ylmethyl)pyrido[3,2-d]pyrimidin-4(3H)-one

: 1367359-28-1
(S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃;
DOI:10.3390/ijms18040768

Reference yield:

: 2105-94-4
4-bromo-2-fluorophenol

: 1367359-18-9
6-chloro-3-[[(3S)-1-isopropyl-3-piperidyl]methyl]-2-methylpyrido[3,2-d]pyrimidin-4-one

: 1367359-28-1
(S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2012.01.078

Reference yield:

: 866775-04-4
3-amino-6-chloropyridine-2-carboxylic acid dihydrochloride

: 1367359-28-1
(S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h / 20 °C

1.2: 20 °C

2.1: Triethyl orthoacetate / 3 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

With benzotriazol-1-ol; caesium carbonate; Triethyl orthoacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.078