Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

Base Information

Chemical Name:Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester
CAS No.:84109-55-7
Molecular Formula:C₂₀H₃₂O₃Si
Molecular Weight:348.558
Hs Code.:

Synonyms:Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

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Technology Process of Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

There total 10 articles about Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (1R,2R,3R)-3-(tert-butyl-dimethyl-silanyloxy)-4-iodo-2-methyl-1-vinyl-butyl ester

: 84109-55-7
Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

Guidance literature:: With sodium tetrahydroborate; In dimethyl sulfoxide; for 12h; Yield given; Ambient temperature;
DOI:10.1021/ja00341a052

Reference yield:

: 84170-92-3
(2R,4aR,6S,7R,8S,8aS)-6-Methoxy-8-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 84109-55-7
Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 75 percent / NBS, BaCO₃ / CCl₄ / 1.5 h / 80 °C

3: Zn / propan-1-ol; H₂O / 0.5 h / 80 °C

4: NaBH₄ / ethanol / 0.5 h / -35 °C

5: pyridine / 12 h / Ambient temperature

6: NaI / butan-2-one / 10 h / 80 °C

7: NaBH₄ / dimethylsulfoxide / 12 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; barium carbonate; sodium iodide; zinc; In pyridine; propan-1-ol; tetrachloromethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone;
DOI:10.1021/ja00341a052

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 84109-55-7
Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-1-vinyl-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 75 percent / NBS, BaCO₃ / CCl₄ / 1.5 h / 80 °C

3: Zn / propan-1-ol; H₂O / 0.5 h / 80 °C

4: NaBH₄ / ethanol / 0.5 h / -35 °C

5: pyridine / 12 h / Ambient temperature

6: NaI / butan-2-one / 10 h / 80 °C

7: NaBH₄ / dimethylsulfoxide / 12 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; barium carbonate; sodium iodide; zinc; In pyridine; propan-1-ol; tetrachloromethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone;
DOI:10.1021/ja00341a052