(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

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Chemical Name:(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester
CAS No.:329326-41-2
Molecular Formula:C₃₃H₄₈N₇O₁₀PSi
Molecular Weight:761.844
Hs Code.:

(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2<i>H</i>-pyrimidin-1-yl)-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

Synonyms:(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

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Chemical Property of (2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

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Technology Process of (2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

There total 4 articles about (2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 329326-38-7
(4-N-benzoyl-3'-O-tert-butyldimethylsilyl)-2'-deoxycytidin-5'-O-yl-(2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethyl)phosphonic acid

: 329326-41-2
(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h; pH=2.7;
DOI:10.1016/S0968-0896(00)00230-3

Reference yield:

: 20924-05-4
thymidyl acetic acid

: 329326-41-2
(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / dicyclohexylcarbodiimide / dimethylformamide / 20 °C

2.1: Me₃SiBr / CH₂Cl₂ / 7 h

2.2: aq. triethylammonium bicarbonate / 0.08 h

2.3: 90 percent / benzyl chloroformate; NaHCO₃ / H₂O

3.1: 50 percent / aq. triethylammonium bicarbonate; 1-adamantanecarbonyl chloride / pyridine / 72 h

4.1: 52 percent / H₂; aq. HCl / Pd/C / methanol / 4 h / 20 °C / pH 2.7

With hydrogenchloride; trimethylsilyl bromide; hydrogen; triethylamine carbonate; 1-Adamantanecarbonyl chloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00230-3

Reference yield:

: 329326-37-6
2-N-(2-N-benzyloxycarbonylaminoethyl)-2-N-(thymin-1-yl-acetyl)aminoethylphosphonic acid

: 329326-41-2
(2-{(2-amino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-ethyl)-phosphonic acid mono-[5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylmethyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / aq. triethylammonium bicarbonate; 1-adamantanecarbonyl chloride / pyridine / 72 h

2: 52 percent / H₂; aq. HCl / Pd/C / methanol / 4 h / 20 °C / pH 2.7

With hydrogenchloride; hydrogen; triethylamine carbonate; 1-Adamantanecarbonyl chloride; palladium on activated charcoal; In pyridine; methanol;
DOI:10.1016/S0968-0896(00)00230-3