(E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

Base Information

Chemical Name:(E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester
CAS No.:274903-80-9
Molecular Formula:C₄₁H₅₇N₃O₃
Molecular Weight:639.922
Hs Code.:

Synonyms:(E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

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Chemical Property of (E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

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Technology Process of (E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

There total 4 articles about (E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-97-0
hexamethylenetetramine

: 274904-27-7
(E)-3-(4-{2-[4-((E)-2-Hexadecylcarbamoyl-vinyl)-phenyl]-2-oxo-acetyl}-phenyl)-acrylic acid tert-butyl ester

: 274903-80-9
(E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

Guidance literature:: With ammonium acetate; acetic acid; In dimethyl sulfoxide; at 100 ℃; for 24h;
DOI:10.1021/jm000508c

Reference yield:

: 143-27-1
hexadecylamine

: 274903-80-9
(E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: TEA / CH₂Cl₂ / 0 - 20 °C

2.1: Pd(OAc)2; TEA; P(o-tolyl)3 / dimethylformamide / 1 h / 100 °C

2.2: Pd(OAc)2; P(o-tolyl)3; TEA / dimethylformamide

3.1: 92 percent / AcOH; NH₄OAc / dimethylsulfoxide / 24 h / 100 °C

With palladium diacetate; TEA; ammonium acetate; acetic acid; tris-(o-tolyl)phosphine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Heck reaction / 2.2: Heck reaction;
DOI:10.1021/jm000508c

Reference yield:

: 21216-80-8
N-cetylacrylamide

: 274903-80-9
(E)-3-(4-{5-[4-((E)-2-hexadecylcarbamoyl-vinyl)phenyl]-1H-imidazol-4-yl}phenyl)-aceylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pd(OAc)2; TEA; P(o-tolyl)3 / dimethylformamide / 1 h / 100 °C

1.2: Pd(OAc)2; P(o-tolyl)3; TEA / dimethylformamide

2.1: 92 percent / AcOH; NH₄OAc / dimethylsulfoxide / 24 h / 100 °C

With palladium diacetate; TEA; ammonium acetate; acetic acid; tris-(o-tolyl)phosphine; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Heck reaction / 1.2: Heck reaction;
DOI:10.1021/jm000508c