(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

Base Information

Chemical Name:(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate
CAS No.:1600566-19-5
Molecular Formula:C₂HF₃O₂*C₂₇H₂₂Cl₂N₄O
Molecular Weight:603.428
Hs Code.:

Synonyms:(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

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Chemical Property of (2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

Chemical Property:

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Technology Process of (2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

There total 6 articles about (2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1600563-23-2
(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone

: 76-05-1
trifluoroacetic acid

: 1600566-19-5
(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

Guidance literature:: 4-bromo-2-methylpyridine; (2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - 0 ℃; for 0.333333h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; Inert atmosphere;

trifluoroacetic acid; In acetonitrile; Inert atmosphere;

Reference yield:

: 2613-89-0
phenylmalonic acid

: 1600566-19-5
(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 0.17 h / 130 °C

2.1: 2 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane; N,N-dimethyl-formamide / 0.5 h / -72 - -71 °C / Inert atmosphere

4.1: TurboGrignard / dichloromethane; tetrahydrofuran / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere

4.2: 0.75 h / 20 °C / Inert atmosphere; Cooling with ice

5.1: manganese(IV) oxide / 1,2-dichloro-ethane / 35 h / 70 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -70 - 0 °C / Inert atmosphere

6.2: Inert atmosphere

6.3: Inert atmosphere

With manganese(IV) oxide; TurboGrignard; n-butyllithium; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1600563-20-9
2,4-dichloro-8-methyl-3-phenylquinoline-6-carbaldehyde

: 1600566-19-5
(2,4-dichloro-8-methyl-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(2-methylpyridin-4-yl)methanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: TurboGrignard / dichloromethane; tetrahydrofuran / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 0.75 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: manganese(IV) oxide / 1,2-dichloro-ethane / 35 h / 70 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -70 - 0 °C / Inert atmosphere

3.2: Inert atmosphere

3.3: Inert atmosphere

With manganese(IV) oxide; TurboGrignard; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;