(1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

Base Information

Chemical Name:(1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene
CAS No.:470474-35-2
Molecular Formula:C₂₆H₃₈O₂S
Molecular Weight:414.653
Hs Code.:

Synonyms:(1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

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Chemical Property of (1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

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Technology Process of (1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

There total 11 articles about (1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 873-55-2
sodium benzenesulfonate

: 470474-34-1
(4aS,5S,8aS)-5-((E)-5-Chloro-4-methyl-pent-3-enyl)-1,1,4a-trimethyl-6-methylene-decahydro-naphthalene

: 470474-35-2
(1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1248/cpb.50.930

Reference yield:

: 31207-72-4
13,14,15,16-tetranorlabd-8⁽¹⁷⁾-en-12-ol

: 470474-35-2
(1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

Guidance literature:: Multi-step reaction with 7 steps

1: 3.698 g / CBr₄; PPh₃ / tetrahydrofuran / 0.25 h / 20 °C

2: 1.035 g / dimethylsulfoxide / 0.5 h / 100 °C

3: 82 percent / diisobutylaluminum hydride / toluene / 0.25 h / -78 °C

4: 99 percent / benzene / 12 h / Heating

5: 99 percent / diisobutylaluminum hydride / toluene / 0.5 h / -78 °C

6: 43 percent / tosyl chloride; DMAP / CH₂Cl₂ / 7 h / 20 °C

7: 93 percent / dimethylformamide / 2 h / 60 °C

With dmap; carbon tetrabromide; diisobutylaluminium hydride; p-toluenesulfonyl chloride; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1248/cpb.50.930

Reference yield:

: 54632-04-1
albicanol

: 470474-35-2
(1'S,2E,4a'S,8a'S)-(+)-3-(1',2',3',4',4a',5',6',7',8',8a'-decahydro-5',5',8a'-trimethyl-2'-methylene-1'-naphthyl)-2-methyl-1-phenylsulfonyl-2-pentene

Guidance literature:: Multi-step reaction with 11 steps

1: 99 percent / 4-dimethylaminopyridine; pyridine / 2 h / 20 °C

2: 49 percent / dimethylsulfoxide / 12 h / 100 °C

3: 89 percent / diisobutylaluminum hydride / toluene / 0.5 h / -78 °C

4: 99 percent / NaBH₄ / methanol / 0.5 h / 0 °C

5: 3.698 g / CBr₄; PPh₃ / tetrahydrofuran / 0.25 h / 20 °C

6: 1.035 g / dimethylsulfoxide / 0.5 h / 100 °C

7: 82 percent / diisobutylaluminum hydride / toluene / 0.25 h / -78 °C

8: 99 percent / benzene / 12 h / Heating

9: 99 percent / diisobutylaluminum hydride / toluene / 0.5 h / -78 °C

10: 43 percent / tosyl chloride; DMAP / CH₂Cl₂ / 7 h / 20 °C

11: 93 percent / dimethylformamide / 2 h / 60 °C

With pyridine; dmap; sodium tetrahydroborate; carbon tetrabromide; diisobutylaluminium hydride; p-toluenesulfonyl chloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1248/cpb.50.930