4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

Base Information

Chemical Name:4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide
CAS No.:1364674-79-2
Molecular Formula:C₁₉H₁₅ClF₃N₃O₄
Molecular Weight:441.794
Hs Code.:

Synonyms:4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

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Chemical Property of 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

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Technology Process of 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

There total 5 articles about 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1364677-00-8
4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

: 2763-95-3
5-aminomethyl-3-methoxyisoxazole hydrochloride

: 1364674-79-2
4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 208519-37-3
2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine

: 1364674-79-2
4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N,N,N,N,N-hexamethylphosphoric triamide; mineral oil / 1.25 h / 20 °C

1.2: 18 h / 120 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 1.5 h / 90 °C / Inert atmosphere

3.1: tetramethylammonium bromide; zinc; acetic acid / 19 h / 50 °C / Inert atmosphere

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 2 h / 35 °C / Aqueous phosphate buffer; Inert atmosphere

4.2: 20 h / 35 °C / Inert atmosphere; Aqueous phosphate buffer

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetramethylammonium bromide; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1364676-94-7
6-chloro-4-iodo-5-(2,2,2-trifluoroethoxy)-2-pyridinemethanol

: 1364674-79-2
4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-methoxy-isoxazol-5-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 1.5 h / 90 °C / Inert atmosphere

2.1: tetramethylammonium bromide; zinc; acetic acid / 19 h / 50 °C / Inert atmosphere

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 2 h / 35 °C / Aqueous phosphate buffer; Inert atmosphere

3.2: 20 h / 35 °C / Inert atmosphere; Aqueous phosphate buffer

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetramethylammonium bromide; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; toluene; acetonitrile;