4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

Base Information

Chemical Name:4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid
CAS No.:1364677-00-8
Molecular Formula:C₁₄H₉ClF₃NO₃
Molecular Weight:331.679
Hs Code.:

Synonyms:4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

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Chemical Property of 4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

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Technology Process of 4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

There total 8 articles about 4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1364676-98-1
4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinemethanol

: 1364677-00-8
4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

Guidance literature:: 4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinemethanol; With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In acetonitrile; at 35 ℃; for 2h; Aqueous phosphate buffer; Inert atmosphere;

With sodium hypochlorite; sodium chlorite; In water; acetonitrile; at 35 ℃; for 20h; Inert atmosphere; Aqueous phosphate buffer;

Reference yield:

: 1364676-94-7
6-chloro-4-iodo-5-(2,2,2-trifluoroethoxy)-2-pyridinemethanol

: 1364677-00-8
4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 1.5 h / 90 °C / Inert atmosphere

2.1: tetramethylammonium bromide; zinc; acetic acid / 19 h / 50 °C / Inert atmosphere

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 2 h / 35 °C / Aqueous phosphate buffer; Inert atmosphere

3.2: 20 h / 35 °C / Inert atmosphere; Aqueous phosphate buffer

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetramethylammonium bromide; sodium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; acetonitrile;

Reference yield:

: 208519-37-3
2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine

: 1364677-00-8
4-(4-chlorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N,N,N,N,N-hexamethylphosphoric triamide; mineral oil / 1.25 h / 20 °C

1.2: 18 h / 120 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 1.5 h / 90 °C / Inert atmosphere

3.1: tetramethylammonium bromide; zinc; acetic acid / 19 h / 50 °C / Inert atmosphere

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 2 h / 35 °C / Aqueous phosphate buffer; Inert atmosphere

4.2: 20 h / 35 °C / Inert atmosphere; Aqueous phosphate buffer

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetramethylammonium bromide; sodium hydride; sodium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; toluene; acetonitrile; mineral oil;