Technology Process of (R)-4-[2-(cyclohex-1-en-1-yl)ethyl]-2,2-dimethyl-1,3-dioxolane
There total 2 articles about (R)-4-[2-(cyclohex-1-en-1-yl)ethyl]-2,2-dimethyl-1,3-dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-4-(1,4-Dithia-spiro[4.5]dec-6-en-7-yl)-butane-1,2-diol;
With
potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III);
potassium osmate(VI); methanesulfonamide;
In
water; tert-butyl alcohol;
at 0 ℃;
2-Methoxypropene;
With
camphor-10-sulfonic acid;
In
N,N-dimethyl-formamide;
for 2h;
With
ammonia; sodium;
In
tetrahydrofuran;
at -78 ℃;
for 0.666667h;
Title compound not separated from byproducts;
DOI:10.1002/anie.200500513
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (DHQD)2PYR; potassium ferricyanide; potassium carbonate / methanesulfonamide; potassium osmate / 2-methyl-propan-2-ol; H2O / 0 °C
2.1: (DHQD)2PHAL; potassium ferricyanide; potassium carbonate / methanesulfonamide; potassium osmate / 2-methyl-propan-2-ol; H2O / 0 °C
2.2: camphorsulfonic acid / dimethylformamide / 2 h
2.3: ammonia; sodium / tetrahydrofuran / 0.67 h / -78 °C
With
hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III);
potassium osmate(VI); methanesulfonamide;
In
water; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation / 2.1: Sharpless asymmetric dihydroxylation;
DOI:10.1002/anie.200500513
![(S)-4-(1,4-Dithia-spiro[4.5]dec-6-en-7-yl)-butane-1,2-diol](/Databaselist/images/loading.webp)
